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Glutathione is a powerful antioxidant often marketed for brighter, more even skin tone and reduction of dark spots from acne or sun damage. While oral glutathione may offer mild skin brightening oral glutathione skin lightening evidence systematic review Full article: as an whitening agent: A randomized, double blind, placebo controlled study Evidence of Glutathione as a Glutathione for skin lightening Dermatologist explains Skin Brightening vs. Whitening: What's Safe & What's Toxic? A 2025 systematic review published in the International Journal of Dermatology evaluated human studies on glutathione for melasma and skin pigmentation published over the past decade. Researchers screened trials from PubMed, Embase

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